The relationship of IL-4- and IFNγ-producing T cells studied by lineage ablation of IL-4-producing cells
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چکیده
منابع مشابه
IL-17 and IL-4 Producing CD8+ T Cells in Tumor Draining Lymph Nodes of Breast Cancer Patients: Positive Association with Tumor Progression
Background: CD8+ cytotoxic T lymphocytes have been recently divided based on their cytokine expression profile. Objective: To evaluate the percentages of CD8+ lymphocytes and their effector subsets including Tc1, Tc2 and Tc17 in the tumor draining lymph nodes (TDLNs) of patients with breast cancer. Methods: Single cell suspensions were obtained from TDLNs of 42 patients with breast cancer. Stai...
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Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to the T helper cell (Th) 2 phenotype, while IL-12 and interferon gamma trigger the differentiation of Th1 cells. However, the source of the initial polarizing IL-4 remains unclear. Here, we show that IL-6, probably secreted by antigen-presenting cells, is able to polarize naive CD4+ T cells to effector...
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IL-17 producers in T cell subsets have been recently identified to play protective roles against bacterial infection by inducing neutrophil infiltrations, organizing granulomas and acquired immunity. During ontogeny, T cells develop, maturate and localize at different tissues depending on V repertoires. V 1+, V 4+ and V 6+ cells are reportedly able to produce IL-17. V 6+ cells, which develop in...
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T cell populations derived from naive mice produce very small amounts of interleukin 4 (IL-4) in response to stimulation on anti-CD3-coated dishes. IL-4 production by such cells is mainly found among large- and intermediate-sized T cells and is dependent upon IL-2. Injection of anti-IgD into mice, a stimulus that leads to striking increases in serum levels of IgG1 and IgE, causes a striking inc...
متن کاملIL-23 drives pathogenic IL-17-producing CD8+ T cells.
IL-17-producing CD8(+) T cells (Tc17) appear to play a role in a range of conditions, such as autoimmunity and cancer. Thus far, Tc17 cells have been only marginally studied, resulting in a paucity of data on their biology and function. We demonstrate that Tc17 and Th17 cells share similar developmental characteristics, including the previously unknown promoting effect of IL-21 on Tc17 cell dif...
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ژورنال
عنوان ژورنال: Cell
سال: 1993
ISSN: 0092-8674
DOI: 10.1016/0092-8674(93)90542-x